On the Michael Addition of Water to α, β??Unsaturated Ketones Using Amino Acids

…, BS Chen, I Degeling, U Hanefeld

Index: Resch, Verena; Seidler, Christiane; Chen, Bi-Shuang; Degeling, Ian; Hanefeld, Ulf European Journal of Organic Chemistry, 2013 , # 34 p. 7697 - 7704

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Citation Number: 6

Abstract

Abstract The use of water as a nucleophile for Michael additions is still a challenge in organic chemistry. In this report we describe the use of amino acids as catalysts for the Michael addition of water to α, β-unsaturated ketones. All 20 proteinogenic amino acids were screened and L-lysine was identified as the best candidate. To obtain a better insight and to determine the minimum requirements of the catalyst, several structurally related ...