Tetrahedron

Regioselective conversion of O-protected glycidols to fluorohydrins catalyuzed by tetrabutylammonium dihydrogentrifluoride under solid-liquid PTC conditions

D Landini, D Albanese, M Penso

Index: Landini, Dario; Albanese, Domenico; Penso, Michele Tetrahedron, 1992 , vol. 48, # 20 p. 4163 - 4170

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Citation Number: 33

Abstract

A number of O-protected glycidols are regioselectively converted into the corresponding fluorohydrins FCH2CH (OH) CH2OX by reaction with catalytic amounts of Bu4N+ H2F3-and a molar excess of KHF2. Most of the protective groups (X) examined are stable under the above conditions, moreover stereogenic carbons are not affected.