Ruthenium??Catalyzed Cycloisomerization of Aromatic Homo??and Bis??Homopropargylic Amines/Amides: Formation of Indoles, Dihydroisoquinolines and …
A Varela??Fernández, JA Varela…
Index: Varela-Fernandez, Alejandro; Varela, Jesus A.; Saa, Carlos Advanced Synthesis and Catalysis, 2011 , vol. 353, # 11-12 p. 1933 - 1937
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Citation Number: 29
Abstract
Abstract Ruthenium-catalyzed cycloisomerizations of aromatic homo-and bis- homopropargylic amines/amides efficiently afford indoles, dihydroisoquinolines and dihydroquinolines. These processes were regioselective (5-and 6-endo cyclizations) on using key Ru vinylidene intermediates. The presence of an amine/ammonium base-acid pair increased the rate of cyclization and facilitated the catalytic turnover.
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