Tetrahedron

Novel synthetic route of aryl-aminopyrazine

M Kuse, N Kondo, Y Ohyabu, M Isobe

Index: Kuse, Masaki; Kondo, Nobuhiro; Ohyabu, Yuki; Isobe, Minoru Tetrahedron, 2004 , vol. 60, # 4 p. 835 - 840

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Citation Number: 17

Abstract

We report a novel synthetic route of aryl-aminopyrazine through a new cyclization reaction by using a hydroxylamine. Starting from Boc-glycine and aminonitrile, the aminopyrazine ring was prepared in several steps. After trifluoromethane sulfonylation of the aminopyrazinone, the resultant triflate was subjected to Suzuki–Miyaura coupling reaction with aryl boronic acid to afford coelenteramine.

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Novel synthetic route of coelenterazines-2-: Synthesis of various dehydrocoelenterazine analogs

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