Studies on pyrrolidinones. On the carbamoylation of some pyroglutamic derivatives

P Cauliez, D Fasseur, D Couturier…

Index: Cauliez, Pascal; Fasseur, Dominique; Couturier, Daniel; Rigo, Benoit; Kolocouris, Antonios Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 4 p. 1233 - 1237

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Abstract

Abstract The carbamoylation of some lactams derivatived from pyroglutamic acid as been studied; better yields were obtained starting from the unsubstitued lactam (toluene, 80) rather than starting with the N-silyllactam (room temperature), although these latter reaction conditions could be interesting for heat sensitive compounds. Methyl and phenyl isothiocyanate react only with the sodium salt of methyl pyroglutamate, giving 1, 5- ...