Synthesis and antitumor activity of novel dithiocarbamate substituted chromones

W Huang, Y Ding, Y Miao, MZ Liu, Y Li…

Index: Huang, Wei; Ding, Yu; Miao, Yan; Liu, Ming-Zhen; Li, Yan; Yang, Guang-Fu European Journal of Medicinal Chemistry, 2009 , vol. 44, # 9 p. 3687 - 3696

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Citation Number: 92

Abstract

A series of chromone derivatives bearing diverse dithiocarbamate moieties were designed and synthesized via a three-component reaction protocol. Their in vitro antitumor activities were evaluated by MTT method against HCCLM-7, Hela, MDA-MB-435S, SW-480, Hep-2 and MCF-7. Two compounds (3-chloro-4-oxo-4H-chromen-2-yl) methyl piperidine-1- carbodithioate (Iq) and (6-chloro-4-oxo-4H-chromen-3-yl) methyl piperidine-1- ...