Gold Catalysis: Switching the Pathway of the Furan??Yne Cyclization

…, M Rudolph, J Huck, W Frey, JW Bats…

Index: Hashmi, A. Stephen K.; Rudolph, Matthias; Huck, Juergen; Frey, Wolfgang; Bats, Jan W.; Hamzic, Melissa Angewandte Chemie - International Edition, 2009 , vol. 48, # 32 p. 5848 - 5852

Full Text: HTML

Citation Number: 84

Abstract

The use of gold compounds as homogeneous catalysts for the conversion of many organic substrates is one of the fastest growing areas in organic chemistry today.[1] Among these transformations, the cyclization of ene–ynes is playing a major role.[2] We developed the gold-catalyzed synthesis of highly substituted phenols, starting from furan–alkyne systems. In this case, as in most of the common ene–yne systems, the first step of the reaction is ...