Journal of Fluorine Chemistry

Henry reaction of fluorinated nitro compounds

H Hu, Y Huang, Y Guo

Index: Hu, Huawei; Huang, Yangen; Guo, Yong Journal of Fluorine Chemistry, 2012 , vol. 133, p. 108 - 114

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Citation Number: 8

Abstract

The Henry (nitroaldol) reaction of fluorinated nitro compounds with various aromatic aldehydes and a fluorinated aliphatic aldehyde to give β-fluoro-β-nitroalcohols which bearing a fluorinated quaternary carbon center was reported. The relative configuration of the major diastereoisomer of 2-fluoro-2-nitro-1-(4-nitrophenyl)-3-phenylpropanol (5bf) was determined by X-ray single crystal analysis.

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