Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents

K Nakagawa-Goto, PC Wu, CY Lai…

Index: Nakagawa-Goto, Kyoko; Bastow, Kenneth F.; Chen, Tzu-Hsuan; Morris-Natschke, Susan L.; Lee, Kuo-Hsiung Journal of Medicinal Chemistry, 2008 , vol. 51, # 11 p. 3297 - 3303

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Citation Number: 16

Abstract

We previously reported that the biological acti-vity of analogues of desmosdumotin B (1) was dramatically changed depending on the B-ring system. A naphthalene B-ring analogue 3 exerted potent in vitro activity against a diverse panel of human tumor cell lines with GI50 values of 0.8− 2.1 μM. In contrast, 1 analogues with a phenyl B-ring showed unique selective activity against P-glycoprotein (P-gp) overexpressing multidrug resistant cell line. ...