Synthesis of selective SRPK-1 inhibitors: novel tricyclic quinoxaline derivatives

…, F Wáczek, P Bánhegyi, B Hegymegi-Barakonyi…

Index: Szekelyhidi, Zsolt; Pato, Janos; Waczek, Frigyes; Banhegyi, Peter; Hegymegi-Barakonyi, Balint; Eros, Daniel; Meszaros, Gyoergy; Hollosy, Ferenc; Hafenbradl, Doris; Obert, Sabine; Klebl, Bert; Keri, Gyoergy; Orfi, Laszlo Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 13 p. 3241 - 3246

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Citation Number: 23

Abstract

SR protein-specific kinase-1 (SRPK-1) has been identified as a validated target for hepatitis B virus (HBV). A series of novel tricyclic quinoxaline derivatives was designed and synthesised as potential kinase inhibitory antiviral agents and was found to be active and selective for SRPK-1 kinase. Most of these novel compounds have drug-like properties according to experimentally determined LogP and LogS values.