Bioorganic & medicinal chemistry letters

Investigations of SCIO-469-like compounds for the inhibition of p38 MAP kinase

S Laufer, F Lehmann

Index: Laufer, Stefan; Lehmann, Frank Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 5 p. 1461 - 1464

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Citation Number: 11

Abstract

The p38 MAP kinase is implicated in the release of the pro-inflammatory cytokines TNFα and IL-1b. Inhibition of cytokine release may be a useful treatment for inflammatory conditions such as rheumatoid arthritis and Crohn's disease. A new lead structure for p38 MAP kinase inhibition was identified. Herein, we report the SAR of this new class of p38 inhibitors.