Acylphosphonates. 4. Synthesis of dithymidine phosphonate. A new method for generation of phosphonate function via aroylphosphonate intermediates

A Kume, M Fujii, M Sekine, T Hata

Index: Kume, Akiko; Fujii, Mitsuo; Sekine, Mitsuo; Hata, Tsujiaki Journal of Organic Chemistry, 1984 , vol. 49, # 12 p. 2139 - 2143

Full Text: HTML

Citation Number: 64

Abstract

Dithymidine phosphonate (10) was synthesized by a new method via dithymidine aroylphosphonates (3) in which the aroyl group served as a protecting group for OPH functions. In a way analogous to the phosphotriester method, 3 was prepared by successive condensation of an aroylphosphonic acid with two kinds of thymidine derivatives. In the last step, the aroyl group was easily removed from 3 by n-butylamine in the presence of a ...