AlCl 3 induced C-arylation/cyclization in a single pot: a new route to benzofuran fused N-heterocycles of pharmacological interest

…, R Adepu, R Kapavarapu, D Rambabu, GR Krishna…

Index: Kumar, K. Shiva; Adepu, Raju; Kapavarapu, Ravikumar; Rambabu; Krishna, G. Rama; Reddy, C. Malla; Priya, K. Krishna; Parsa, Kishore V.L.; Pal, Manojit Tetrahedron Letters, 2012 , vol. 53, # 9 p. 1134 - 1138

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Citation Number: 7

Abstract

A new and one-pot synthesis of benzofuran fused N-heterocycles has been accomplished via AlCl3-mediated C–C followed by C–O bond formation between 2, 3-dichloropyrazine or its derivatives and phenols. The methodology provided novel compounds as potential inhibitors of PDE4B. The single crystal X-ray data of a synthesized benzofuran derivative are presented. Scope of the methodology, in vitro pharmacological data of some of the ...