Triple-helical transition state analogues: a new class of selective matrix metalloproteinase inhibitors

…, K Brew, JK Whitehead, S Li, RP Hammer…

Index: Li, Shunzi; Whitehead, John K.; Hammer, Robert P. Journal of Organic Chemistry, 2007 , vol. 72, # 8 p. 3116 - 3118

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Citation Number: 42

Abstract

Alterations in activities of one family of proteases, the matrix metalloproteinases (MMPs), have been implicated in primary and metastatic tumor growth, angiogenesis, and pathological degradation of extracellular matrix (ECM) components, such as collagen and