7-Oxabicyclo [2.2. 1] heptyl carboxylic acids as thromboxane A2 antagonists: aza. omega.-chain analogs

M Nakane, JA Reid, WC Han, J Das…

Index: Nakane, Masami; Reid, Joyce A.; Han, Wen-Ching; Das, Jagabandhu; Truc, Vu Chi; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2465 - 2476

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Citation Number: 24

Abstract

A2 (TxA,) receptor antagonist. Unlike the related series of w-chain allylic alcohols, amide 7 and its congeners were uniformly free of direct contractile activity in vitro (bovine coronary) and in vivo (anesthetized guinea pig). Amide 7 was effective in the inhibition of (a) arachidonic acid induced platelet aggregation of human platelet-rich plasma (I,= 0.18 f 0.006 pM),(b) 11, 9-epoxymethano-PGH2 induced platelet aggregation of human platelet-rich ...