Geminal acylation-alkylation at a carbonyl carbon via regiospecifically generated metalloenamines

…, GW Phillips, TA Puckette, JA Colapret

Index: Martin, Stephen F.; Phillips, Gerald W.; Puckette, Thomas A.; Colapret, John A. Journal of the American Chemical Society, 1980 , vol. 102, # 18 p. 5866 - 5872

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Citation Number: 37

Abstract

Abstract: A useful procedure for effecting geminal disubstitution at the carbonyl carbon atom of aldehydes and ketones has been developed in which the sequence of reactions results in the replacement of the two carbon-oxygen bonds of the carbonyl function with an acyl group and an alkyl or hydroxyalkyl group. Of particular importance is the facile application of these procedures to the efficient construction of quaternary carbon atoms that bear alkyl ...