Antitumor agents. Part 3: Synthesis and cytotoxicity of new trans-Stilbene benzenesulfonamide derivatives

LM Yang, SJ Lin, FL Hsu, TH Yang

Index: Yang, Li-Ming; Lin, Shwu-Jiuan; Hsu, Fen-Lin; Yang, Tsang-Hsiung Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1013 - 1015

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Citation Number: 27

Abstract

A new series of trans-stilbene benzenesulfonamide derivatives were designed and synthesized as potential antitumor agents. These new compounds were evaluated in the National Cancer Institute's 60 human tumor cell line in vitro screen. Compounds 9–13 were cytotoxic against several cell lines. Notably, two compounds, 9 and 12, demonstrated selective cytotoxic activity against BT-549 breast cancer (GI50= 0.205 μM) and HT–29 ...