Direct conversion of carboxylic acids into amides

PA Grieco, DS Clark, GP Withers

Index: Grieco,P.A. et al. Journal of Organic Chemistry, 1979 , vol. 44, p. 2945 - 2947

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Citation Number: 19

Abstract

HCN phosphonium cyanidle I by reaction with the carboxylic acid), which reacts with the amine present to produce the corresponding amide and tri-n-butylphosphine oxide. The procedure is generally carried out employing 1.5 equiv of amine in tetr, ahydrofuran containing 1.5 equiv of o-nitrophenyl thiocyanate and 1.5 equiv of freshly distilled tri-n- butylphosphine. The reaction, which proceeds under mild conditions, has been performed ...