Il Farmaco

2-(dialkylamino)-4H-1-benzopyran-4-one derivatives modify chloride conductance in CFTR expressing cells

M Mazzei, E Nieddu, C Folli, E Caci, LVJ Galietta

Index: Mazzei, Mauro; Nieddu, Erika; Folli, Chiara; Caci, Emanuela; Galietta, Louis V.J. Farmaco, 2003 , vol. 58, # 9 p. 961 - 970

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Citation Number: 4

Abstract

Some 2-(diethylamino)-7-hydroxy-4H-1-benzopyran-4-one derivatives, potentially useful as activators of the cystic fibrosis transmembrane conductance regulator (CFTR), were prepared. The synthesized compounds were tested, together with others 2-(dialkylamino)-7- hydroxybenzopyran-4-one derivatives, by measuring their capacity to modify the kinetics of iodide influx in Fisher rat thyroid cells expressing wild type CFTR and the halide-sensitive ...