Phenylacetone as Building Blocks in Heterocyclic Synthesis: Synthesis of Polyfunctionally-Substituted Pyridines, and fused Pyridines

AM Hussein, EA Ishak, AA Atalla, SA Hafiz…

Index: Hussein; Ishak; Atalla; Hafiz, S. Abdel; Elnagdi Phosphorus, Sulfur and Silicon and the Related Elements, 2007 , vol. 182, # 12 p. 2897 - 2917

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Citation Number: 13

Abstract

Many pyridinethiones are biologically active. In view of our interest in developing efficient syntheses of polyfunctionally substituted heteroaromatics utilizing the readily obtainable enaminone 3 as starting materials. So, treatment of enaminone 3 with cyanothioacetamide or cyanoacetamide afforded the pyridinethione 5a and pyridone 5b. compound 5a reacted with α-halo-ketones in refluxing sodium ethoxide to give the thienopyridine derivatives 9a ...