Bioresponsive deciduous-charge amphiphiles for liposomal delivery of DNA and siRNA

P Pierrat, D Kereselidze, P Wehrung, G Zuber…

Index: Pierrat, Philippe; Kereselidze, Dimitri; Wehrung, Patrick; Zuber, Guy; Pons, Francoise; Lebeau, Luc Pharmaceutical Research, 2013 , vol. 30, # 5 p. 1362 - 1379

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Citation Number: 6

Abstract

ABSTRACT Purpose Biolabile cationic lipids were developed for efficient intracellular delivery of DNA and siRNA. Methods The compounds have been designed starting from the membrane lipid DOPC in a way they may loose their cationic charge when exposed to an acidic and/or enzymatic stimulus, such as those met during the journey of a lipoplex in biological media. Results They demonstrated remarkable efficiency to deliver DNA in ...