Journal of Heterocyclic Chemistry

Optimized palladium??based approaches to analogues of PK 11195

S Guillou, YL Janin

Index: Guillou, Sandrine; Janin, Yves L. Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 5 p. 1377 - 1384

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Citation Number: 6

Abstract

The peripheral-type benzodiazepine receptor ligands such as PK 11195 and Ro 5-4864 were found more than twenty years ago in the course of research on neurobiology. These ligands were instrumental in pointing out an involvement of the peripheral-type benzodiazepine receptor (PBR) in apoptosis processes. With in mind an improvement of the solubility of PK 11195 in biological media, we report here improved reaction conditions for ...