Cyclization Reaction for the Synthesis of Polysubstituted Naphthalenes in the Presence of Au (I) Precatalysts

AR Jagdale, JH Park, SW Youn

Index: Jagdale, Arun R.; Park, Jong Hyub; Youn, So Won Journal of Organic Chemistry, 2011 , vol. 76, # 17 p. 7204 - 7215

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Citation Number: 30

Abstract

Au (I)-catalyzed cyclization of alkenyl carbonyl compounds leading to a variety of substituted naphthalenes has been developed. This process exploits a dual function of the Au (I) catalyst:(1) the oxophilic nature of the Au (I) catalyst, counterintuitive to the π-acidic reactivities generally associated with Au catalysts, and (2) olefin isomerization supported by the outcome of isotope scrambling experiments. It cannot be completely excluded that ...