Tetrahedron

An one-pot approach to the synthesis of triazolobenzothiadiazepine 1, 1-dioxide derivatives by basic alumina-supported azide–alkyne [3+ 2] cycloaddition

KC Majumdar, S Ganai, B Sinha

Index: Majumdar; Ganai, Sintu; Sinha, Biswajit Tetrahedron, 2012 , vol. 68, # 38 p. 7806 - 7811

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Citation Number: 8

Abstract

An efficient one-pot strategy for the synthesis of triazolobenzothiadiazepine 1, 1-dioxide derivatives has been developed by the reaction of 2-azido-N-substituted benzenesulfonamides and propargyl bromide in basic alumina under microwave condition via [3+ 2] azide–alkyne cycloaddition reaction. This protocol has synthetic advantages in terms of low environmental impact and short reaction time.