POTENTIAL ANTICANCER AGENTS III. URETHANE-TYPE NITROGEN MUSTARDS OF SOME SYNTHETIC ESTROGENS

I Niculescu-Duvăz, V Feyns, E Grant…

Index: Niculescu-Duvaz,I. et al. Canadian Journal of Chemistry, 1966 , vol. 44, p. 1102 - 1105

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Citation Number: 3

Abstract

While studying the anticancer activity of the urethane-type nitrogen mustards, n:e prepared a nuillber of conlpounds of this type fro111 synthetic estrogens, with the purpose of establishing a relationship between the estrogenic activity of the bis-hydroxyphenyl derivatives and the anticancer action of their nitrogen mustard carban~ates. Since com- pounds I and I1 that had previously been prepared (I) exhibited 50-60y0 inhibitions on Walker carcinosarco~na 256 (2), it ...