A new strategy for the synthesis of furan-3, 4-dicarboxylic acid
AM Deshpande, AA Natu, NP Argade
Index: Deshpande, Anil M.; Natu, Arvind A.; Argade, Narshinha P. Synthesis, 2002 , # 8 p. 1010 - 1012
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Citation Number: 14
Abstract
Abstract A facile route to furan-3, 4-dicarboxylic acid is described. Dimethylmaleic anhydride (1) on NBS-bromination followed by aqueous KOH treatment gave bis (hydroxymethyl) maleic anhydride (3), which on intramolecular Mitsunobu ring closure followed by esterification and DDQ-oxidation furnished the desired esters of furan-3, 4-dicarboxylic acid 7a/b.
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