The synthesis and potassium channel blocking activity of some (4-methanesulfonamidophenoxy) propanolamines as potential class III antiarrhythmic agents

SP Connors, PD Dennis, EW Gill…

Index: Connors, Sean P.; Dennis, Paul D.; Gill, Edward W.; Terrar, Derek A. Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1570 - 1577

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Citation Number: 15

Abstract

The synthesis of 22 (4-methanesulfonamidophenoxy) propanolamines and their testing on isolated guinea pig cardiac myocytes, on isolated preparations from guinea pig atria, and on rat blood pressure are described. Secondary amines in the series (1 la-f) showed residual@- blocking activity, whereas incorporation of N-methyl phenylalkyl and 4-phenyl alicyclic amine groups abolished@-blocking activity but led to enhanced ability to block the ...