Synthetic chalcones, flavanones, and flavones as antitumoral agents: Biological evaluation and structure–activity relationships

M Cabrera, M Simoens, G Falchi, ML Lavaggi…

Index: Cabrera, Mauricio; Simoens, Macarena; Falchi, Gabriela; Lavaggi, M. Laura; Piro, Oscar E.; Castellano, Eduardo E.; Vidal, Anabel; Azqueta, Amaia; Monge, Antonio; de Cerain, Adela Lopez; Sagrera, Gabriel; Seoane, Gustavo; Cerecetto, Hugo; Gonzalez, Mercedes Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 10 p. 3356 - 3367

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Citation Number: 234

Abstract

A series of synthetic chalcones, flavanones, and flavones has been synthesized and evaluated for antitumor activity against the human kidney carcinoma cells TK-10, human mammary adenocarcinoma cells MCF-7 (estrogen receptor-positive), and human colon adenocarcinoma cells HT-29. The most active series is the chalcone ones with the best results against TK-10 and HT-29 cells. Fourteen out of 53 analyzed compounds resulted ...