Archives of pharmacal research

Synthesis of novel 4-(1H-benzimidazol-2-yl) benzene-1, 3-diols and their cytotoxic activity against human cancer cell lines

MM Karpińka, J Matysiak, A Niewiadomy

Index: Karpinka, Monika M.; Matysiak, Joanna; Niewiadomy, Andrzej Archives of Pharmacal Research, 2011 , vol. 34, # 10 p. 1639 - 1647

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Citation Number: 6

Abstract

Abstract One-pot synthesis of new biologically active 4-(1 H-benzimidazol-2-yl) benzene-l, 3- diols has been developed. The compounds were prepared by the reaction of aryl-modified sulfinylbis [(2, 4-dihydroxyphenyl) methanethione] s with benzene-l, 2-diamines. Their structures were identified using elemental, IR, 1 H-NMR, and mass spectra analyses. The developed method offers short reaction times, relatively large-scale synthesis, easy and ...

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