Tetrahedron

A straightforward approach to unsaturated carboxylic acid derivatives starting from bis-silylated precursors

A De Girolamo, V Fiandanese, G Marchese, A Punzi

Index: De Girolamo, Annalisa; Fiandanese, Vito; Marchese, Giuseppe; Punzi, Angela Tetrahedron, 1998 , vol. 54, # 40 p. 12399 - 12408

Full Text: HTML

Citation Number: 3

Abstract

A new synthetic approach to substituted unsaturated carboxylic acid derivatives, such as amides, nitriles and esters, has been developed, starting from easily accessible bis-silylated precursors. The key step was based upon the reaction of a bis-silylated diene and a bis- silylated enyne with chlorosulphonyl isocyanate, which afforded mono-silylated amides, easily converted into substituted nitriles and esters.