Cytotoxic 3, 6-bis ((imidazolidinone) imino) acridines: synthesis, DNA binding and molecular modeling

…, D Sabolová, J Ungvarský, H Paulíková…

Index: Janovec, Ladislav; Kozurkova, Maria; Sabolova, Danica; Ungvarsky, Jan; Paulikova, Helena; Plsikova, Jana; Vantova, Zuzana; Imrich, Jan Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1790 - 1801

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Citation Number: 49

Abstract

New acridine derivatives bearing two symmetrical imidazolidinone rings, 3, 6-bis ((1-alkyl-5- oxo-imidazolidin-2-yliden) imino) acridine hydrochlorides 6a–6e (alkyl= ethyl, n-propyl, n- butyl, n-pentyl, n-hexyl), have been prepared and their interactions with calf thymus DNA and selected cell lines were studied. The DNA-binding of 6a–6e to ctDNA was examined by UV–vis, fluorescence, and CD spectroscopy. The binding constants determined by UV–vis ...