Synthesis and quantitative structure-activity relationship of a novel series of small conductance Ca2+-activated K+ channel blockers related to dequalinium

D Galanakis, CA Davis, CR Ganellin…

Index: Journal of Medicinal Chemistry, , vol. 39, # 2 p. 359 - 370

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Citation Number: 35

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. Scheme 1 shows the synthesis of compounds 1−3, 7a, 7, 8, 13−15, 18, and 20. Either 4-chloroquinoline or 4-chloroquinaldine was treated with the necessary diamine to provide compounds 1−3 and 7a. ...