Naphthylchalcones induce apoptosis and caspase activation in a leukemia cell line: The relationship between mitochondrial damage, oxidative stress, and cell death

…, RJ Nunes, RA Yunes, TB Creczynski-Pasa

Index: Winter, Evelyn; Chiaradia, Louise Domeneghini; De Cordova, Clarissa A.S.; Nunes, Ricardo Jose; Yunes, Rosendo Augusto; Creczynski-Pasa, Tania Beatriz Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 22 p. 8026 - 8034

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Citation Number: 32

Abstract

In this study, we investigated the effects of 24 chalcone derivatives from 2- naphthylacetophenone toward a lymphoblastic leukemia cell line (L1210). Three compounds, called R7, R13, and R15, presented concentration-and time-dependent cytotoxicity and induced cellular death by apoptosis via mitochondrial injury and oxidative stress. The effects of these compounds appear to occur through different mechanisms ...