Synthesis of 3??phenyl??5??(trifluoromethyl) isoxazole and 5??phenyl??3??(trifluoromethyl) isoxazole
…, JA Lowell, V Ervithayasuporn
Index: Pavlik, James W.; Lowell, Jennifer A.; Ervithayasuporn, Vuthichai Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 7 p. 1253 - 1255
Full Text: HTML
Citation Number: 7
Abstract
Abstract Reaction of 4, 4, 4-trifluoro-1-phenyl-1, 3-butanedione with hydroxylamine led to the formation of 5-hydroxy-3-phenyl-5-(trifluoromethyl)-4, 5-dihydroisoxazole which was dehydrated to 3-phenyl-5-(trifluoro-methyl) isoxazole. This isomer can also be synthesized by reaction of 4-chloro-4-phenyl-1, 1, 1-trifluoro-3-buten-2-one with sodium azide. The regioisomer, 5-phenyl-3-(trifluoromethyl) isoxazole was synthesized by reaction of 1, 1, 1- ...
Related Articles:
A one-pot synthesis of 3-trifluoromethyl-2-isoxazolines from trifluoromethyl aldoxime
[Goncalves, Raoni S. B.; Dos Santos, Michael; Bernadat, Guillaume; Bonnet-Delpon, Daniele; Crousse, Benoit Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 2387 - 2394]
Cycloadditions of trifluoroacetonitrile oxide with olefins and acetylenes.
[Tanaka; Masuda; Mitsuhashi Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 8 p. 2184 - 2187]
Synthesis of fluorinated heterocycles
[Sloop, Joseph C.; Bumgardner, Carl L.; Loehle, W. David Journal of Fluorine Chemistry, 2002 , vol. 118, # 1-2 p. 135 - 147]
Synthesis of isomeric trifluoromethyl pyrazoles and isoxazoles
[Diab, Joseph; Laurent, Andre; Drean, Isabelle Le Journal of Fluorine Chemistry, 1997 , vol. 84, # 2 p. 145 - 147]
Cycloadditions of trifluoroacetonitrile oxide with olefins and acetylenes.
[Tanaka; Masuda; Mitsuhashi Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 8 p. 2184 - 2187]