5-HT1 and 5-HT2: binding characteristics of some quipazine analogs
RA Glennon, RM Slusher, RA Lyon…
Index: Glennon, Richard A.; Slusher, R. M.; Lyon, Robert A.; Titeler, Milt; McKenney, J. D. Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2375 - 2380
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Citation Number: 86
Abstract
Arylpiperazines, such as 1-(3-trifluoromethylphenyl) piperazine (TFMPP) and its chloro analogue mCPP, are 5-HT1 agonists, whereas quipazine, Le., 2-(l-piperazino) quinoline, appears to be a 5-HT, agonist. Radioligand binding studies using rat cortical membrane homogenates and drug discrimination studies using rats trained to discriminate a 5-HT1 agonist (ie, TFMPP) or a 5-HT2 agonist (ie, 1-(2, 5-dimethoxy-4-methylphenyl)-2- ...
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