A novel one-pot conversion of amines to homologated esters in poly (ethylene glycol)
S Chandrasekhar, GPK Reddy, C Nagesh, CR Reddy
Index: Chandrasekhar; Pavan Kumar Reddy; Nagesh; Raji Reddy Tetrahedron Letters, 2007 , vol. 48, # 7 p. 1269 - 1271
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Citation Number: 14
Abstract
The first deaminative homologation of amines (–CH2NH2) to esters (–CH2CH2COOEt) in one-pot is reported. The reaction proceeds through, formation of an aldehyde from an amine in the presence of Pd/C as catalyst followed by Wittig reaction and catalytic hydrogenation using poly (ethylene glycol) as the solvent in one-pot.
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