N-linked glycoside/glucuronide conjugates of retinoids: acitretin
V Balakrishnan, NE Gilbert, RW Brueggemeier…
Index: Balakrishnan; Gilbert; Brueggemeier; Curley Jr. Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 23 p. 3033 - 3038
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Citation Number: 6
Abstract
Glucuronide conjugates of retinoids have been found to be active metabolites of the parent molecules. However, O-acylglucuronide retinoids are liable to hydrolysis and retinoid ring oxidation. We have prepared stable N-linked glycosides of acitretin in efforts to overcome these problems. The synthesis and preliminary biological studies of the analogs are reported.
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