Synthesis of 3??Arylindole??2??carboxylates via Copper??Catalyzed Hydroarylation of o??Nitrophenyl??Substituted Alkynoates and Subsequent Cadogan Cyclization

Y Yamamoto, S Yamada…

Index: Yamamoto, Yoshihiko; Yamada, Satoshi; Nishiyama, Hisao Advanced Synthesis and Catalysis, 2011 , vol. 353, # 5 p. 701 - 706

Full Text: HTML

Citation Number: 7

Abstract

Abstract A two-step route to biologically important 3-arylindole-2-carboxylic esters has been successfully established: o-nitrophenyl-substituted alkynoates underwent copper-catalyzed hydroarylation in the presence of commercially available arylboronic acids to afford 3, 3- diarylacrylates, which were then converted to indolecarboxylates via a modified Cadogan cyclization using a molybdenum catalyst and triphenylphosphine.