A concise synthetic route to polyfunctional γ-ketoester derivatives via methoxy (phenylthio) methyl-lithium

S Hackett, T Livinghouse

Index: Hackett, Steven; Livinghouse, Tom Journal of the Chemical Society, Chemical Communications, 1986 , # 1 p. 75 - 76

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Abstract

The a,@-unsaturated 0,s-acetals obtained via the reaction of methoxyphenylthiomethyl-lithium with 3-alkoxyenones are readily convertible into structurally diverse y-ketoesters by way of an efficient alkylation-hydrolysis sequence. ... Recently we required a concise and general procedure for the preparation of @-substituted-y-ketoesters (1) and their synthetic equivalents. Intermediates such as (1) were expected to be available by way of a three step sequence involving the ...