Tetrahedron

Stereoselective synthesis of β-ketoesters from prop-2-yn-1-ols

C Darcel, C Bruneau, PH Dixneuf, SM Roberts

Index: Darcel, Christophe; Bruneau, Christian; Dixneuf, Pierre H.; Roberts, Stanley M. Tetrahedron, 1997 , vol. 53, # 27 p. 9241 - 9252

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Citation Number: 8

Abstract

The activation of allylic prop-2-yn-1-ols by the [Ru (μ-O2CH)(CO) 2 (PPh3)] 2 catalyst in the presence of carboxylic acids leads to unsaturated β-ketoesters in one step. The utilization of optically active prop-2-yn-1-ols provides a new stereoselective access to optically active β- ketoesters with retention of configuration at the propargylic carbon.