2??amino??X??nitrobenzimidazoles as precursors of food??borne carcinogens: A new approach to IQ synthesis

M Bella, V Milata, LI Larina

Index: Bella, Maros; Milata, Viktor; Larina, Lyudmila I. Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 2 p. 293 - 296

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Citation Number: 4

Abstract

Abstract Cyclization of (non)-methylated nitro-o-phenylenediamines with cyanogen bromide provided nitro-substituted 2-aminobenzimidazoles in good up to excellent yields. Catalytic hydrogenation of 2-amino-1-methyl-5-nitrobenzimidazole yielded 2, 5-diamino-1- methylbenzimidazole, which on treatment with 1, 1, 3, 3-tetramethoxypropane in methanol and subsequently after removal of methanol in polyphosphoric acid afforded food-borne ...