Synthesis of diaryl ethers through the copper-promoted arylation of phenols with arylboronic acids. An expedient synthesis of thyroxine
DA Evans, JL Katz, TR West
Index: Evans, David A.; Katz, Jeffrey L.; West, Theodore R. Tetrahedron Letters, 1998 , vol. 39, # 19 p. 2937 - 2940
Full Text: HTML
Citation Number: 645
Abstract
Diaryl ethers are readily synthesized in high yield at room temperature through the copper (II)-promoted coupling of arylboronic acids and phenols. The reaction is tolerant of a wide range of substituents on both coupling partners. These reaction conditions permit the racemization-free arylation of phenolic amino acids, methodology that has been applied to an efficient synthesis of thyroxine.
Related Articles:
[Verma, Sanny; Kumar, Neeraj; Jain, Suman L. Tetrahedron Letters, 2012 , vol. 53, # 35 p. 4665 - 4668]
[Verma, Sanny; Kumar, Neeraj; Jain, Suman L. Tetrahedron Letters, 2012 , vol. 53, # 35 p. 4665 - 4668]