Preneoplastic lesions, DNA adduct formation and mutagenicity of 5-, 7-and 9-hydroxy-2-nitrofluorene, metabolites of the air pollutant 2-nitrofluorene

XS Cui, J Bergman, L Möller

Index: Cui, Xian-Shu; Bergman, Jan; Moeller, Lennart Mutation Research - Genetic Toxicology, 1996 , vol. 369, # 3-4 p. 147 - 155

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Citation Number: 18

Abstract

The metabolites of 2-nitrofluorene (NF), 5-, 7-and 9-OH-2-nitrofluorene (OH-NF) were compared for their genotoxicity. Seventy-two hours after intraperitoneal administration of these substances individually to rats (100 mg/kg body wt.), DNA adducts in liver tissue were analyzed with 32P-TLC and 32P-HPLC. An in vivo liver model was used to test the initiating capacity of the said substances for the formation of preneoplastic lesions. 5-OH-NF ...