Synthesis of Ring A??Modified Baicalein Derivatives

JF Wang, N Ding, W Zhang, P Wang…

Index: Wang, Jun-Fei; Ding, Ning; Zhang, Wei; Wang, Peng; Li, Ying-Xia Helvetica Chimica Acta, 2011 , vol. 94, # 12 p. 2221 - 2230

Full Text: HTML

Citation Number: 8

Abstract

Abstract Baicalein, an important active constituent of the traditional Chinese herb Scutellaria baicalensis, exhibited antitumor activity and inhibitory activity against P-gp 170. The syntheses of 25 baicalein derivatives, 2–26 (Table), are described here (Scheme 1). These compounds were systematically modified with O-alkylation and O-acylation at HO [BOND] C (5), HO [BOND] C (6), and HO [BOND] C (7), singly or in combination, on the ring A of ...