Further delineation of hydrophobic binding sites in dopamine D 2/D 3 receptors for N-4 substituents on the piperazine ring of the hybrid template 5/7-{[2-(4-aryl- …

B Ghosh, T Antonio, B Gopishetty, M Reith…

Index: Ghosh, Balaram; Antonio, Tamara; Gopishetty, Bhaskar; Reith, Maarten; Dutta, Aloke Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 15 p. 5661 - 5674

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Citation Number: 12

Abstract

Here we report a structure–activity relationship (SAR) study of analogues of 5/7-{[2-(4-aryl- piperazin-1-yl)-ethyl]-propyl-amino}-5, 6, 7, 8-tetrahydro-naphthalen-2-ol. Our SAR is focused on introduction of various substitutions in the piperazine ring of the hybrid template. The goal behind this study is to delineate the nature of the binding pocket for N-aryl substitution in the piperazine ring by observing the effect of various hydrophobic and other ...