Natural product research

Microbial metabolism. Part 10: Metabolites of 7, 8-dimethoxyflavone and 5-methoxyflavone

W Herath, J Rakel Mikell, I Ahmad Khan

Index: Herath, Wimal; Rakel Mikell, Julie; Ahmad Khan, Ikhlas Natural Product Research, 2009 , vol. 23, # 13 p. 1231 - 1239

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Citation Number: 5

Abstract

Microbial transformation of 7, 8-dimethoxyflavone (1) by Mucor ramannianus produced five metabolites: 7, 8-dimethoxy-4′-hydroxyflavone (2), 3′, 4′-dihydroxy-7, 8- dimethoxyflavone (3), 7, 3′-dihydroxy-8-methoxyflavone (4), 7, 4′-dihydroxy-8- methoxyflavone (5) and 8-methoxy-7, 3′, 4′-trihydroxyflavone (6). It was, however, completely converted to a single metabolite, 7-hydroxy-8-methoxyflavone (7) by ...