Journal of the American Chemical Society

2-Bromopyrazines, 2-Cyanopyrazines and their Derivatives

G Karmas, PE Spoerri

Index: Karmas; Spoerri Journal of the American Chemical Society, 1956 , vol. 78, p. 2141,2144

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Citation Number: 9

Abstract

After 2-hydroxypyrazines had become readily acces~ ible,~*~ our interest in this field centered on the conversion of these compounds to useful derivatives. A previous publication3 discussed the synthesis of 2-chloropyrazines by reaction of hydroxypyrazines with phosphorus oxychloride. When it was found that displacement of chlorine by the cyano group could not be satisfactorily accomplished the conversion of hydroxypyrazines to ...