Tetrahedron Letters

Dynamic kinetic resolution of hemiaminals with axially chiral twisted amides

S Yamada, E Noguchi

Index: Yamada, Shinji; Noguchi, Emiko Tetrahedron Letters, 2001 , vol. 42, # 21 p. 3621 - 3624

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Citation Number: 18

Abstract

Dynamic kinetic resolution of N-acylhemiaminals was performed by enantioselective acylation of the hydroxy groups with chiral twisted amides. The stereoselectivity was reversed in the presence of 4-DMAP. The absolute configuration of the products was determined based on the sign of CD Cotton effects.