A Practical Synthesis of α-Aryl Methyl Ketones via a Transition-Metal-Free Meerwein Arylation
…, PD O'Shea, JF Marcoux, R Angelaud…
Index: Molinaro, Carmela; Mowat, Jeffrey; Gosselin, Francis; O'Shea, Paul D.; Marcoux, Jean-Francois; Angelaud, Remy; Davies, Ian W. Journal of Organic Chemistry, 2007 , vol. 72, # 5 p. 1856 - 1858
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Citation Number: 55
Abstract
We report herein a simple, scalable, transition-metal-free approach to the synthesis of α-aryl methyl ketones from diazonium tetrafluoroborate salts under mild conditions. This methodology uses easily accessible and nontoxic starting material and was applied to the multi-kilogram-scale preparation of 1-(3-bromo-4-methylphenyl) propan-2-one.
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