Tetrahedron letters

A mild procedure for the production of secondary amines from oximes and benzisoxazoles

M Searcey, SS Grewal, F Madeo, PG Tsoungas

Index: Searcey, Mark; Grewal, Sukhwant S.; Madeo, Fiorenza; Tsoungas, Petros G. Tetrahedron Letters, 2003 , vol. 44, # 35 p. 6745 - 6747

Full Text: HTML

Citation Number: 16

Abstract

2-Hydroxybenzaldoximes are reduced under mild conditions of ammonium formate/Pd–C in methanol to give secondary amines. Benzisoxazoles react under the same mild conditions to give the same products. A possible mechanism is suggested, involving the intermediacy of the benzisoxazole in the oxime conversion.